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Project Discovery: Challenging & Interesting Samples

First post
Author
etgfrogs
Dreddit
Test Alliance Please Ignore
#181 - 2016-05-06 05:30:30 UTC
The most obvious cell to cell variation Ends up being 18% community consensus on cell the cell variation.Shocked
HPA Dichroic
H P A
C C P Alliance
#182 - 2016-05-06 10:35:20 UTC
Hmmm, that is an obvious one! Do you have the image ID? I'd love to know what that protein's job is biologically.

I know the community seems to shy away from CCD, and that 's largely our fault since we don't train it very well as we haven't been annotating it in the past. Fear not though! I am currently working on an optimized cut-off for each class for the statistical significance required to consider a response. This should help with general community bias such as over-annotation of cytoplasm and under-annotation of CCD.

Keep marking em! o7
Kolmogorow
Freedom Resources
#183 - 2016-05-06 11:24:21 UTC
Yesterday I had my first clear centrosome image (mainly double-dots, but in some cells only one dot)! They seem to be quite rare. One question about them: I've read on Wikipedia that the centrosome "serves as the main microtubule organizing center (MTOC)". But in PD there is also the "microtubule organizing center" as a separate image classification (more a diffuse ball rather than one or two sharp dots). Hence I thought centrosome and MTOC would be two different biological objects. Are they actually the same organelle and only the green staining is sometimes sharp and sometimes diffuse for some reason?
etgfrogs
Dreddit
Test Alliance Please Ignore
#184 - 2016-05-06 20:28:37 UTC  |  Edited by: etgfrogs
HPA Dichroic wrote:
Hmmm, that is an obvious one! Do you have the image ID? I'd love to know what that protein's job is biologically.

I know the community seems to shy away from CCD, and that 's largely our fault since we don't train it very well as we haven't been annotating it in the past. Fear not though! I am currently working on an optimized cut-off for each class for the statistical significance required to consider a response. This should help with general community bias such as over-annotation of cytoplasm and under-annotation of CCD.

Keep marking em! o7

I cant find how to get the image ID. I've found nothing on reddit, I'm not getting a response in game. I keep feeling like it is a simple answer.

Edit. Found where it was, guess I was just blind. It was in the lower right after the results screen.

I also found another odd one. Image ID 100481373: This looks to be both nucleoplasm and nucleoli in different cells.
HPA Dichroic
H P A
C C P Alliance
#185 - 2016-05-11 09:31:37 UTC
Beta Maoye wrote:
I think the classification of this image is wrong. It is not Nucleus. It should be Mitochondria.



This image has been correct in-game. Sorry it took so long to get a system in place for updating these, they should go faster in the future. Thanks for your feedback!
HPA Dichroic
H P A
C C P Alliance
#186 - 2016-05-11 09:36:37 UTC
March rabbit wrote:
I've heard that some images was analyzed by professionals? Shocked
screenshot



This has now been officially updated in-game. We now have a system, so updates should happen faster. Thanks for the help and keep em coming!
HPA Dichroic
H P A
C C P Alliance
#187 - 2016-05-11 09:41:37 UTC
Beta Maoye wrote:
In this classification result, I realized I was wrong about Cytoplasm for so many cases.



This has now been officially updated in-game. We now have a system, so updates should happen faster. Thanks for the help and keep em coming!
Shiverwarpz
The Scope
Gallente Federation
#188 - 2016-05-12 17:04:57 UTC
I've had a couple tough classifications in a row now. This one http://i.imgur.com/xElpvSz.png (100457139)

in particular had me questioning myself. I've always had trouble with cytoskeleton intermediate filaments VS Endoplasmic reticulum, but never the cytoskeleton microtubules. What exactly makes this one microtubules over the filaments? (The cytokinetic bridge is pretty obvious here)

And while I'm on the subject, the classification I had a few slides before, had me questioning between cell junctions and focal adhesions. How can I more clearly make that distinction? If that classification is correct, then sometimes cell junctions can appear even when not next to another cell (Just black space on the slide)
Galaxxis
Unicorn Rampage
#189 - 2016-05-24 21:25:08 UTC
http://i.imgur.com/FmMBfrk.jpg

This one has little stringy things all over the place that look like mitochondria, but it's tagged as vesicles.
HPA Illuminator
H P A
C C P Alliance
#190 - 2016-05-25 20:03:15 UTC
Galaxxis wrote:
http://i.imgur.com/FmMBfrk.jpg

This one has little stringy things all over the place that look like mitochondria, but it's tagged as vesicles.


What you see here is actually a certain type of vesicles called peroxisomes, so the control is right.

If you find control images that you think are incorrect, it would be great if you could make a post in this reddit thread.

o7
HPA Illuminator
H P A
C C P Alliance
#191 - 2016-05-25 20:12:56 UTC  |  Edited by: HPA Illuminator
Shiverwarpz wrote:
I've had a couple tough classifications in a row now. This one http://i.imgur.com/xElpvSz.png (100457139)

in particular had me questioning myself. I've always had trouble with cytoskeleton intermediate filaments VS Endoplasmic reticulum, but never the cytoskeleton microtubules. What exactly makes this one microtubules over the filaments? (The cytokinetic bridge is pretty obvious here)

And while I'm on the subject, the classification I had a few slides before, had me questioning between cell junctions and focal adhesions. How can I more clearly make that distinction? If that classification is correct, then sometimes cell junctions can appear even when not next to another cell (Just black space on the slide)


Sorry for the late reply, didn't see this until now!

If you would toggle the green/red on/off you would see that there is a perfect overlap of individual strands which would lead one to the conclusion of microtubules.

Cell junctions should only appear where two cells are touching each other, not when there's black next to the cells. Focals would normally appear somewhat under the cell, not just at/outside the edge of it (and they can appear regardless whether the cell has neighbors or not).

The reddit subthread https://www.reddit.com/r/ProjectDiscovery/ is a great place for asking questions. Also, our PD classes (first at youtube and second/third at twitch (until 20160606) might be helpful!).

EDIT: LOL, didn't see the name first. Guessing you can probably ignore most of this after our posts on reddit :)
Galaxxis
Unicorn Rampage
#192 - 2016-05-25 21:45:54 UTC
HPA Illuminator wrote:
Galaxxis wrote:
http://i.imgur.com/FmMBfrk.jpg

This one has little stringy things all over the place that look like mitochondria, but it's tagged as vesicles.


What you see here is actually a certain type of vesicles called peroxisomes, so the control is right.

If you find control images that you think are incorrect, it would be great if you could make a post in this reddit thread.

o7


Oh cool! Thanks for the info.
Shiverwarpz
The Scope
Gallente Federation
#193 - 2016-05-25 22:59:43 UTC
HPA Illuminator wrote:


Sorry for the late reply, didn't see this until now!

If you would toggle the green/red on/off you would see that there is a perfect overlap of individual strands which would lead one to the conclusion of microtubules.

Cell junctions should only appear where two cells are touching each other, not when there's black next to the cells. Focals would normally appear somewhat under the cell, not just at/outside the edge of it (and they can appear regardless whether the cell has neighbors or not).

The reddit subthread https://www.reddit.com/r/ProjectDiscovery/ is a great place for asking questions. Also, our PD classes (first at youtube and second/third at twitch (until 20160606) might be helpful!).

EDIT: LOL, didn't see the name first. Guessing you can probably ignore most of this after our posts on reddit :)


Hahaha, yeah, this was my very first post when getting into Project Discovery. Learned a lot since then!
Joia Crenca
Science and Trade Institute
Caldari State
#194 - 2016-05-28 14:45:08 UTC
I'll bring this over from the other thread in the Information Center

Joia Crenca wrote:
I noticed that some of the Classification Samples are a bit questionable, still. I guess someone is noticing when one comes up with a large 'incorrect' percentage as pertains to players trying to identify it?

Also, when do I get my certificate of cell sample mastery from the University of Reykjavik? Blink



I guess I need to go check Reddit myself. Is CCP finished with any further work on the mini-game? The reason I ask is I'm wondering if more helpful information could be a part of the module itself?

Thanks folks!
HPA Illuminator
H P A
C C P Alliance
#195 - 2016-05-31 07:49:39 UTC
Joia Crenca wrote:
I'll bring this over from the other thread in the Information Center

Joia Crenca wrote:
I noticed that some of the Classification Samples are a bit questionable, still. I guess someone is noticing when one comes up with a large 'incorrect' percentage as pertains to players trying to identify it?

Also, when do I get my certificate of cell sample mastery from the University of Reykjavik? Blink



I guess I need to go check Reddit myself. Is CCP finished with any further work on the mini-game? The reason I ask is I'm wondering if more helpful information could be a part of the module itself?

Thanks folks!


We're really dependent on your input for finding questionable control images, so please report them at the reddit thread I mentioned a few posts ago.

Hehe, certficates do sound like a nice idea (although guess it might be us at KTH (Royal Institute of Technology) here in Stockholm that are responsible for the science part).

I don't know if they are finished, but feedback is always appreciated. There are some PD threads here at the EVE forum where people have been commenting on it earlier, but I think they've been quiet for a month or so now at least.
Ashlar Maidstone
MoonFyre BattleGroup Holdings
#196 - 2016-06-01 05:09:40 UTC
Hi, I just started today Project Discovery and so far made it to rank 4! My question is how long will this be available because this is something I been wanting to do since it was introduced earlier this year. And will there be more projects like this? Thank youBig smile
HPA Illuminator
H P A
C C P Alliance
#197 - 2016-06-03 09:27:09 UTC
Ashlar Maidstone wrote:
Hi, I just started today Project Discovery and so far made it to rank 4! My question is how long will this be available because this is something I been wanting to do since it was introduced earlier this year. And will there be more projects like this? Thank youBig smile


Yay, welcome to PD! (in case you haven't come across them there's a PD subreddit, an awesome ingame chat channel (search for Project Discovery) - great for asking questions about difficult images, and also a slack channel)

CCP has said that PD will be around as long as it's popular, so hopefully that means for a long time :)

As for more projects like this, I don't know. That's up to CCP.

Hope you'll enjoy it (and let us know if you have questions :))
o/
William Weatherwax
Spear of Selene
#198 - 2016-06-06 15:50:40 UTC
Kolmogorow wrote:
Yesterday I had my first clear centrosome image (mainly double-dots, but in some cells only one dot)! They seem to be quite rare. One question about them: I've read on Wikipedia that the centrosome "serves as the main microtubule organizing center (MTOC)". But in PD there is also the "microtubule organizing center" as a separate image classification (more a diffuse ball rather than one or two sharp dots). Hence I thought centrosome and MTOC would be two different biological objects. Are they actually the same organelle and only the green staining is sometimes sharp and sometimes diffuse for some reason?



Hi Kolmogorow,

the centrosome is both. In the beginning it will be a ball but once the cell division starts it will separate and each part will migrate to the opposite poles of the cell. While doing this they are connected by the microtubuli.
HPA Illuminator
H P A
C C P Alliance
#199 - 2016-06-07 13:41:05 UTC  |  Edited by: HPA Illuminator
William Weatherwax wrote:
Kolmogorow wrote:
Yesterday I had my first clear centrosome image (mainly double-dots, but in some cells only one dot)! They seem to be quite rare. One question about them: I've read on Wikipedia that the centrosome "serves as the main microtubule organizing center (MTOC)". But in PD there is also the "microtubule organizing center" as a separate image classification (more a diffuse ball rather than one or two sharp dots). Hence I thought centrosome and MTOC would be two different biological objects. Are they actually the same organelle and only the green staining is sometimes sharp and sometimes diffuse for some reason?



Hi Kolmogorow,

the centrosome is both. In the beginning it will be a ball but once the cell division starts it will separate and each part will migrate to the opposite poles of the cell. While doing this they are connected by the microtubuli.



That was a great reply!

I just want to add that MTOC differs from centrosomes (since we can't distinguish the individual centriole/s), so it could be e.g. a protein in the pericentriolar matrix which is surrounding the centrosome, or vesicles that are clustering around the centrosomes.
Joia Crenca
Science and Trade Institute
Caldari State
#200 - 2016-07-16 05:18:49 UTC
I'm actually still doing this Project. I'll have to check whether the last update I've seen to the ranks coincides with reward updates. (I'm sitting on a lot of Analysis Kredits, lol)