Macintosh

If you're running EVE under Cider, there's a lot to do beyond playing around with the graphics settings in the client (these have been covered fairly extensively, but I've included my setup). With these tweaks I've been able to boost frame rate to well over 100 fps under full graphics settings and improve overall stability (no lockups or crashes until some of the recent updates). In heavy asteroid environments with dozens of NPC ships it still typically clocks in at 60-80 fps.
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These are my EVE settings graphical settings:

✖ Use multithreaded OpenGL (this is known to increase instability)
Present Interval » Interval Immediate
✓ Turrest & Launchers
✓ Effects
✓ Missile Effects
✓ Ship Explosions
✓ Drone Models
✖ Trails
✓ GPU Particles
✓ Asteroid Environments
✓ Light Rays
✓ Inspace Skinning Effect

✓ Resource Cache Enabled (this may improve stability and avoid freezing)
✖ HDR Enabled (enabling this is a huge performance hit)

Anti-Aliasing » Medium
Post Processing » High
Shader Quality » Medium (I run medium because there are some graphic anomalies under high)
Texture Quality » High
LOD Quality » High
Shadow Quality » High (set this to low or disable to massively increase performance)
Interior Effects » High
Interior Shader Quality » High
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DISCLAIMER: Use the following at your own risk! CCP cannot provide support if you screw something up. That being said, this is also why we backup the original config file first! Note that all variables with respect to RAM should be divisible by 128. My AMD Radeon R9 card has 4096MB, so the examples reflect my configuration (follow the instructions as noted).

cd ~/Library/Application\ Support/EVE\ Online
cp config config.backup
open config

Note: If you screwed something up, this is how you restore the backup:
cp -R config.backup config

Search (Command-F) for "MaxVRAM", uncomment this line and change the value:

;"MaxVRAM" = "0"

to whatever the VRAM is for your graphics card:

"MaxVRAM" = "4096"

Next search for "VideoRam" and change the value to reflect half the VRAM for your graphics card (note: do not set this to the full value of your video card, as it will crash EVE on launch):

"VideoRam" = "256"

to

"VideoRam" = “2048”

Next, change the line immediately below that to one half of the above value:

"AGPVertexRam" = “128”

to

"AGPVertexRam" = “1024”

And yes, these are NOT typos. Cider is setup to use zero VRAM and only 128/256MB of your graphics card by default.

Voila! Save (Command-S) and you're off to the races! This will get you the bulk of any performance increases under Cider, and it's literally a night and day improvement. You can also tweak these variables if you feel adventurous (depending on your graphics card, you may or may not see additional benefits).

"sRGBInPixelShader" = “1” » "sRGBInPixelShader" = “2”
;"VertexShaderMode" = "H" » "VertexShaderMode" = "H"
"ForceMOVACompliance" = "N" » "ForceMOVACompliance" = "Y"
;"DepthTextures" = "Y" » "DepthTextures" = "Y"
;"VolumeTextures" = "Y" » "VolumeTextures" = "Y"
;"ForceMaxSamples" = "16" » "ForceMaxSamples" = "16"
"MTD3D" = “0” » "MTD3D" = “1”

Last but not least, if you want to check over your changes - you can run the following command (this will generate a file you can view that compares the old and new values):

diff config config old >> differences.txt

Enjoy and good luck! Comments welcome, cheers!

Yes, well - in the interim...