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organ transplant question
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irishFour
Almost Dangerous
#1 - 2013-12-08 02:06:20 UTC
if you receive a transplanted appendage or organ, do all the cells eventually get replaced by cells with your dna in it

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Eurydia Vespasian
Storm Hunters
#2 - 2013-12-08 02:48:43 UTC
this is probably the best question I have ever seen in oope lol

I don't really know the answer, to be honest. But, that said, I would lean towards that as the donor tissue is living and viable most of the replacement parts regeneration would come from it and not the host. But I really don't know. now I am curious lol
Jarod Garamonde
Jolly Codgers
Get Off My Lawn
#3 - 2013-12-08 03:59:30 UTC
irishFour wrote:
if you receive a transplanted appendage or organ, do all the cells eventually get replaced by cells with your dna in it


Yes, to an extent.
How long it takes honestly depends on your age. The younger you are, the more stem cells you produce, and that is the determining factor. For older recipients, this process may never actually complete. For younger recipients (especially children and adolescents), it only takes a couple years at most.

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Eurydia Vespasian
Storm Hunters
#4 - 2013-12-08 04:10:32 UTC
are you suuuuere?

because I believe incompatibilities between donor tissue and recipient tissue dna are the very reason that immunosuppressant drugs are required for the rest of the hosts life after a transplant. the hosts body will attack the donated organ or other body part as a foreign invader. part of the rejection process. now, i could be incorrect. I have been part of organ donor cases but no transplants. but that seems logical to me. Question
Surfin's PlunderBunny
Sebiestor Tribe
Minmatar Republic
#5 - 2013-12-08 04:31:32 UTC
It's like the Borg

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Onyx Nyx
Trillium Invariant
Honorable Third Party
#6 - 2013-12-08 09:46:34 UTC
Short answer: No.

There are some exceptions of tiny fractions of cells, but by and large, the organs remain the donor's DNA. There's some evidence that recipient cells can (at very low frequencies) also contribute to the new organ. Renewal of the organ typically comes from the donor cells, not from the recipient. That's why patients have to remain on anti-rejection drugs for the rest of their lives.

One major exception to this is bone grafts. Those are typically just killed donor bone, which provides a matrix for host cells to incorporate and use as the substrate for new bone.

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Ishtanchuk Fazmarai
#7 - 2013-12-08 11:12:45 UTC
Onyx Nyx wrote:
Short answer: No.

There are some exceptions of tiny fractions of cells, but by and large, the organs remain the donor's DNA. There's some evidence that recipient cells can (at very low frequencies) also contribute to the new organ. Renewal of the organ typically comes from the donor cells, not from the recipient. That's why patients have to remain on anti-rejection drugs for the rest of their lives.

One major exception to this is bone grafts. Those are typically just killed donor bone, which provides a matrix for host cells to incorporate and use as the substrate for new bone.


That. If our body could replace a missing organ by growing back the necessary cells, then we wouldn't need no transplants.

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Mizhir
Devara Biotech
#8 - 2013-12-08 13:35:38 UTC
irishFour wrote:
if you receive a transplanted appendage or organ, do all the cells eventually get replaced by cells with your dna in it


No, the organ will keep it's original DNA and will keep the same "signature". Which is a huge problem as the reciever's own immune system will start destroying the tissue if nothing is done to prevent it with medicine that suppress the immune system. It is the reason why the doctors have to find a close match as the closer the DNA "signature" is, the easier it is to slow down the destruction of the new organ.

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Krixtal Icefluxor
INLAND EMPIRE Galactic
#9 - 2013-12-08 13:43:13 UTC
"There are some exceptions of tiny fractions of cells, but by and large, the organs remain the donor's DNA. There's some evidence that recipient cells can (at very low frequencies) also contribute to the new organ. Renewal of the organ typically comes from the donor cells, not from the recipient. That's why patients have to remain on anti-rejection drugs for the rest of their lives."

Does the tissue from a transplant retain the DNA of the donor or change to that of the host?

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Kyseth
Viziam
Amarr Empire
#10 - 2013-12-10 20:32:54 UTC
Surfin's PlunderBunny wrote:
It's like the Borg


I think you mean Viidian.