Ships & Modules

Use Toon 1 (with drones skills) in a Dominix and use Toon 2 in a brawler:

Toon 1 jumps out with an MJD, launches sentries and sets them to assist Toon 2.
Toon 2 then tanks and kills whatever comes its way.

You will not have to watch Toon 1 much and can play comfortably with Toon 2 and have the full DPS of drones to assist you.

If Toon 2 can fly battleships as well, then quite possibly you might be best served by putting Toon 1 into a Dominix instead of a Megathron - leverage the heavy drone skills that way, and perhaps also carry salvage and logistics drones, and put Toon 2 into another battleship or a Tengu for pure fire support. Or if Toon 2 can fly a Marauder of some flavor, then use that as your salvage platform, or perhaps put Toon 2 into a Myrmidon with tractors and logi, salvage, and combat drones.

ED: oops, ninja'd.

As to Toon 2 lacking the connections to get L4's, that's no problem. So long as Toon 1 and Toon 2 are fleeted up, Toon 1 can lead the way to the in-gate for the mission complex, and then let Toon 2 take the lead. If rewards are split, then that'll also help buff Toon 2's standings.

Can be a Tengu, but can be a Loki or a Proteus, too. A Loki can web and paint the target for full drone damage and the Proteus can bring extra DPS for killing frigates and cruisers faster. Mission-/agent-wise is it not an issue. Just make sure Toon 1 gets the mission items before completing the mission, if there are any.

Also, do not launch the drones before you jump out, but after you have jumped or else they likely get aggro. Use 3 omnis with the Dominix's bonuses and Garde IIs will hit as far as 90km.

No, use the Dominix. Only it has got the bonus you need for doing this:

Gallente Battleship skill bonus per level:
10% bonus to Drone Damage and Drone hitpoints
10% bonus to Drone optimal range and Drone tracking speed

if you fit domi the right way it can provide you with 800 dps from drones and then if you don't mind loosing out dps from tengu you can fit it with bunch of 48km tractors and salvagers 4 mopping wrecks on the go.

1600 afk deepz!

Tengu RS combo works great. Tengu can shoot cruiser down and RS(or domi) shoots BS down. Reason I say RS over domi is you can fit a decent shield tank and still have space for 4 x DDA's in the lows. When I did this I used HML's int he tengu and made the RS cap stable with a large SB. Assign drones to assist tengu so you don't have to keep switching over. Split 1 launcher away from the group and use it to get the assigned drones shooting. Use sentries for this.
Didn't use HAM's as I didn't want to be limited to to range and have to keep switching ammo... but whatever works

I use a T2 MJD sentry Domi and an Ishtar. The main reason I fly these two ships is because of their ability to apply damage to almost all rat types via Sentries. Another advantage is that your drones are not affected by tracking disruptors and ECM if you set their aggression accordingly. Also, Ishtar may be outclassed by cheaper hulls like a prophecy in terms of isk efficiency but i prefer to fly a HAC. For blood/sansha I just whip out my baddon or paladin, assist drones from Domi, and melt missions in 5-10 min(full clear). If you can just bookmark a wreck in each room and run 5- 10 missions then come back and hoover up salvage and loot with your noctis if you have one. I like to salvage like this to give myself a quick break between mission sets. Rinse/repeat for 20-60 mil/hour depending on your playstyle/skillset. Feel free to criticize me, but this is my cup of tea.

TL:DR Domi-Ishtar for most missions, Domi-any lazor ship for blood/sansha

edit: I have found that my efficiency has went up by 50% since using the paladin combo since i can just tractor wrecks to a single spot and this lets me fit more salvagers on my noctis (6salvager 2's/ 2 Tractor 2's).

Pro tip: I have found that my fav skill for mission boats is Multitasking. Being able to lock up all frigs/dessies in missions at once saves minutes/mission.

OP, before you click this link, I want you to ask yourself: how hoss are you feeling today.

this is a setup with two possible cruiser drone boats, and three possible shot-callers. you didn't say what empire you are in, and I'm in Caldari space, so I used caldari resists. this is to consider going smaller, not bigger:

features:

-target painters on the frigates--cycle time on TPs is 10 s so you'll need to alternate. they're for activating the assisted sentries.
-oversized afterburners to speed/sig tank.
-tractor beams cuz you mentioned salvage.
-core probe launchers cuz you strike me as the type who would like to do some relaxing explo (i do).
-matching drone control range, TP range, and drone bunny targeting range.
-T2 drone damage augs and omni tracking links, cuz you don't want to skimp there.
-small sig resolutions and sig radiuses, excellent tracking--means very well-applied DPS.
---(1000 paper dps from sentries and torps will feel more like 2000 dps)

how you fly this setup:

warp in, get transversal, release sentries, initiate locks, assist drones, alternate F1 F2 on frigs. you'll be flying away from your sentries and scooping them up after the room is done.

kill frigs first, especially webs first. you'll know which frigs to prioritize by the speed they're coming at you/how eager they are to do bad things up close

the cruiser and frigates' speeds are similar-ish. if you're going to maintain a large radius arc for transversal, you can get away with setting the frigate to approach the cruiser and follow. you probably don't want the cruiser chasing the frig, because the frig will get away from you, making the cruiser's transversals sloppy, and you'll have to keep track of two sets of ranges.

or, you could limit the frigate's speed and have the drone boat follow, so that you're only controlling one ship/screen.

both drone boats have a 100km drone control range. their targeting ranges, while shorter than their drone control ranges, are fine where they are; when your drones are set to assist, your drones will fire at their target as long as the drone boat and the drones are within drone control range of the target. I tested this myself not more than a week ago.

the harpy and raptor require the targeting range script. the manticore requires the scan resolution script. (in fact, I suggest the manticore)

the ishtar and gila drone info/specs are identical--tracking, optimal, etc.

damage and resist profiles are optimal against gurista, mercs, mordu, serpentis, ...and CONCORD. ...

in the case of EM damage, those are from turrets weapons, and aside from changing your weapon damage type, you should be able to speed/sig tank and also use range to take on the EM laz0r weapon types.

special notes:
-the harpy WILL survive. I run L4 harpys all the time.
-harpy and crow get targeting range script. manticore gets scan res script.
-to be honest, the raptor is just there to emphasize the idea of a small fast locking drone bunny.
-with both the assault frig and manticore, obviously you end up chewing on cruisers and battleships together. the manticore allows you to contribute DPS sooner, from range.
-I prefer the manticore option, due to its ability to fire javelin torps to damn near 90km (effective range)
--with Rage torps loaded, its DPS is 250.
-if you see spider drones in non-drone missions, kill those immediately. they web from 75km.
-I'm about to try the manticore/gila setup myself.

--Lastly, another option I did not think to try was using a scimitar or oneiros (depending on whether you're armor or shields) as the drone bunny. they have ridiculously tiny sigs, and cap stable transfers.and you'll only need one.

actually... worm and scimi options with gila. the worm/gila combo has an active tank on top of the sig/speed tank. plus they can both equip tractors and salvage drones.

(however, i did not verify the shield maintenance bots' orbit speed. one sec. //their orbit velocity is 420, could be a problem.)

also: kinetic and thermic Pithum c-type shield amps are very cheap--2 mil and 7 mil in jita iirc. I just have a habit of avoiding deadspace in EFT.

Like Mama Guru said, The Mach and the Domi are just awesome together. I have always wanted to try two Domi's. 10 sentry drones would be pretty nasty.