Missions & Complexes

there isnt one in my opinion. best payout u will receive from agents in .5 if u wanna only run in hs.
There are mission hubs but there is also the chance the highest to encounter gankers.
And best LP ration use Lp store or lp store calculator

Sisters of Eve are pretty much always the highest isk/LP in highsec, with sporradic market fluctuations causing some exceptions to that rule.

Full disclosure: I periodically gank the **** out of that particular system with friends and corpmates because it's a haven for bling-pinata mission ships. If you're planning on pimp fitting something to bring out, I'd refrain from donig so in US or EU prime, make several bookmarks for undocking and inspecting gates, and avoid combat probes, aggressive drones, or launching an MTU as all of those things will increase the odds you'll be one of my victims.

You may be wondering why i'm giving the game away. Well, odds are good you won't heed my advice in full and even if you do, most players out there don't, even after they lose a ship or two.

Good luck and hope to see you soon.

As stated 0.5 agents give the best rewards in terms of LP and the most consistent high LP/ISK conversion is SOE.

Overall the best way of converting SOE LP to ISK tends to be buying Sisters Probes and Sisters Launchers and selling those. However occasionally the prices of Astero will jump up making them a good way to cash in.

If your flying a Domi then the 0.5 SOE IV agent at Lanngisi is particularly optimal as the best sentry for use with the new omni's is the Bouncer which happen to match well the Angel mission types you get a lot in Lanngisi.

Downside of Lanngisi is the prices are a touch low in Hek/Rens. However its a simple matter to save up the LP and every few days make an intie run or clone jump to Dodi or Amarr to cash in.

The other downside of Lanngisi is its only two jumps from the 'nado ganker gangs based around Hek. Avoid faction modules and you will be fine.

Generally speaking, the best systems to mission in are with Sisters of Eve Level 4 Agents because they have a stable high-value LP store. There are a few choices, Lanngisi, Osmon and Apananke. Osmon is very popular because it's close to Jita. Personally I would go with Lanngisi because it's in Minmatar space so you'll mostly face Angel rats which are by far the best rats to mission against, they come right up in your face so you can run close range gank setups (AC Mach absolutely demolishes Angel missions) to maximize your efficiency, and their E-War is a joke (unlike Guristas/Serpentis/Sansha which can be a huge pain). Lanngisi is also a 0.5 system IIRC so you get better LP/Mission reward payouts than Osmon. It's also not too far from Hek which isn't as good as Jita, but a decent tradehub. However gankers know this as well so don't fly something stupidly pimped, I used to fly a Mach with 3x RF Gyrostabs and a Pith C-Type X-Large shield booster as the only pimp on it and never had any attempted ganks so unless you fly with a massive amount of pimp modules you'll be fine.

I would not count on Hek as your local trade hub. There are often shortages of mission running related equipment / ammunition in there. For example, T2 logi drones or the other night both Hek and Rens were all out of T2 Cruise launchers. Granted it's something like 4th or 5th largest hub so the volumes are probably not good enough for many people to bother with it.

Lanngisi is good spot, in general, as when you hit 4h timer there is a minmatar L4 combat agent from Krusual tribe next door in Nakugard who can entertain you meanwhile. Eventually running for sisters drags your standings with minmatar high enough if you do not want to get standings up for Krusual specifically. There is also Amarr L4 sec agent in Barkrik for standings balancing if you need it. However - there is a significant quirk in there which can cut into your isk/h by some amount depending on what hardware you are using and how fast you do them - Barkrik is huge system, sisters agent just loves to send you there and if you are in a BS you can spend about minute and half in warp to your mission in Barkrik and that same minute and half for getting back to Lanngisi. Mach is a bit better in that regard ofc and/or T2 warp speed rigs can be quite reasonable investment if you are in pimp enough ride to blitz missions in less than 15-10 minute on average.

For the part yes. The agent tends to send you on missions against the local rats, however there is some bias. If I run for a Caldari agent in Minmatar space I will get a sprinkle of Gurista missions. For the SOE you tend to get Sepentis for the sprinkle.

You will be offered faction missions, in addition to the every 15 missions storyline mission. These are solely based upon the agent affiliation. SOE sends you against Amarr & Caldari. If you don't want standing hits to these factions you have to decline those missions.

Yeah you will get missions based mostly on the local rat type (Minmatar System > Angel Missions) however as previously mentioned you will get a sprinkling of other factions which in SoE case is Serpentis. You will also get the standard 'factionless' missions (Drones, Mercenaries etc). Another great way to supplement your income is to use ProSynergy to salvage and loot your missions for you while you blitz them in a high dps ship.

As I said previously I'd recommend the Mach, it has the higher base warp speed which with the recent changes, plays a huge part in your mission efficiency. I'd slap some T2 warp speed rigs on there as well.

It's kind of relative to what you are flying. Even at Lanngisi a T1/T2 fitted Domi is reasonably safe. I have heard of T2 fitted marauders being ganked but even that is rare. Once you add even a single cheapish faction mod that will change however and deadspace or officer mods are like painting a target on yourself.

If you only have the one mission ship and cannot afford to replace it by all means play it safe, however the original question was "most profitable mission system" and the answer to that is Lanngisi providing you do not fly shiney.

probably far away from trade hubs